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. 2021 Jul 20;22(9):e52252. doi: 10.15252/embr.202052252

Figure 4. SOCS6 participates in anti‐Mtb immunity.

Figure 4

  • A, B
    Survival of Mir342 −/− B6 and Mir342 −/− B6 mice supplemented with Socs6 siRNA (n = 10) (A), or Mir342 +/+ C3H and Mir342 +/+ C3H mice supplemented with SOCS6‐overexpressing vector (n = 10) (B), after aerosol infection with around 400 CFU Mtb. Data are shown as the Kaplan–Meier curves.
  • C, D
    Mtb bacterial loads in lungs, spleens, and livers of Mir342 −/− B6 and Mir342 −/− B6 mice supplemented with Socs6 siRNA (C), or Mir342 +/+ C3H and Mir342 +/+ C3H mice supplemented with SOCS6‐overexpressing vector (D) at 21 dpi. Data are shown as the medians ± interquartile ranges of n = 3 biological replicates.
  • E, F
    Tuberculosis lung lesions of Mir342 −/− B6 and Mir342 −/− B6 mice supplemented with Socs6 siRNA (E), or Mir342 +/+ C3H and Mir342 +/+ C3H mice supplemented with SOCS6‐overexpressing vector (F) at 21 dpi were detected by hematoxylin/eosin staining. Representative images from n = 3 biological replicates are shown. Scale bar = 100 μm.

Data information: Log‐rank (Mantel–Cox) test (A, B) and Mann–Whitney U test (C, D) were used for data analysis. **P < 0.01.