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. 2021 Jul 20;22(9):e52252. doi: 10.15252/embr.202052252

Figure 8. A20‐mediated cell death mechanism is independent of inflammatory responses.

Figure 8

  • A, B
    Production of cytokines TNF‐α, IL‐1, IL‐6, CXCL15 (A), or chemokines Ccl5, Cxcl10, Icam1 (B) in the A20 −/− Socs6 +/+, A20 +/+ Socs6 +/+, A20 −/− Socs6 −/−, and A20 +/+ Socs6 −/− BMDMs after Mtb stimulation. Data are shown as the mean ± SEM of n = 3 biological replicates.
  • C–E
    Cell death mechanisms (C), cell viabilities (D), or Mtb growth rates (E) of A20 −/− Socs6 +/+, A20 +/+ Socs6 +/+, A20 −/− Socs6 −/−, and A20 +/+ Socs6 −/− BMDMs stimulated with Mtb. Z‐VAD treatment concentration was 20 μM, and the treatment time was 24 h. Data are shown as the mean ± SEM of n = 3 biological replicates.
  • F
    Schematic representation of miR‐342 regulated anti‐Mtb immunity.

Data information: ANOVA followed by Bonferroni post hoc test (A‐E) was used for data analysis. *P < 0.05, **P < 0.01. Abbreviation: n.s., not significant.