TABLE 2.
Neuropsychological screening – descriptive statistics and group comparison.
|
SCA1+2 (n = 18)
|
ILOCA (n = 16)
|
HC (n = 34)
|
SCA1+2 - HC
|
ILOCA - HC
|
||||
| Mean/Median (sd) | Range | Mean/Median (sd) | Range | Mean/Median (sd) | Range | t | t | |
| Global cognitive functioning | ||||||||
| MMSE1 | 27.2/27.5 (2.8) | 19–30 | 27.8/27.5 (1.7) | 25–30 | 29.1/30 (1.2) | 27–30 | 16.428* | 15.22* |
| ACE-R-total2 | 82.6/85.5 (12.0) | 56–99 | 89.9/89 (4.9) | 80–98 | 95.9/97(4.2) | 86–100 | 29.601** | 19.41** |
| Learning and episodic verbal memory3 | ||||||||
| FCSRT-total free recall | 20.6/20.5 (6.8) | 5–33 | 22.1/22.5 (4.9) | 15–32 | 29.2/34 (6.9) | 8–40 | 23.662** | 19.756** |
| FCSRT-delayed free recall | 8.4/8.5 (2.7) | 5–13 | 10.4/10 (2.5) | 5–15 | 11.3/12 (2.6) | 4–15 | 19.941** | |
| FCSRT-recognition | 14.4/14.5 (1.7) | 12–16 | 15.5/16 (1.5) | 10–16 | 15.9/16 (0.2) | 15–16 | 17.905** | |
| ACE-R-verbal memory | 21.7/23 (4.9) | 6–26 | 23.3/23 (2.2) | 19–26 | 25.3/26 (1.4) | 21–26 | 22.26** | 17.774** |
| Orientation and attention | ||||||||
| ACE-R-orientation and attention | 16.6/17 (1.8) | 12–18 | 17.3/17.5 (0.9) | 16–18 | 17.6/18 (0.7) | 16–18 | ||
| TMT-A | 83.6/74 (36.6) | 30–157 | 49.3/42.5 (17.0) | 22–82 | 33.4/30 (14.7) | 18–78 | 31.183** | 17.169* |
| Digit-span | 7.7/8 (2.1) | 4–11 | 8.3/8 (2.9) | 4–13 | 11.3/11.5 (2.1) | 7–15 | 24.977** | 20.088** |
| Calculation | ||||||||
| Arithmetic-VITI4 | 9.1/9 (3.2) | 3–14 | 11.3/11 (1.6) | 9–14 | 13.8/14 (0.5) | 12–14 | 32.647** | 24.014** |
| Language | ||||||||
| ACE-R-language | 23.2/25 (3.2) | 15–26 | 24.8/25 (0.8) | 24–26 | 25.4/26 (1.2) | 22–26 | 17.188** | |
| BNT-Total | 50.3/52 (6.4) | 40–58 | 53.3/54 (3.1) | 45–57 | 54.4/55 (3.9) | 40–59 | ||
| Visuospatial processing | ||||||||
| HVOT5 | 17.2/17 (6.3) | 8–25 | 21.3/21.5 (3.1) | 16–25 | 24.6/25 (2.9) | 17–29 | 26.103** | 18.39** |
| ACE-R-visuospatial skills | 13.2/14 (3.1) | 8–16 | 15.3/16 (1.0) | 13–16 | 15.3/16 (1.4) | 11–16 | 14.634** | |
| Executive functions | ||||||||
| SCWT6 | 91.6/90 (37.6) | 45–154 | 97.3/98 (41.2) | 36–180 | 57.9/53.5 (21.5) | 10–98 | 18.088** | 19.488** |
| DOT Total7 | 5.3/5 (1.9) | 2–9 | 6.0/6 (1.3) | 4–9 | 7.9/8 (2.1) | 4–12 | 23.5** | 18.188** |
| ACE-R-phonemic fluency | 3.8/4 (1.6) | 1–7 | 4.4/4 (1.5) | 2–7 | 5.7/6 (0.9) | 4–7 | 23.034** | 17.086* |
1Mini Mental State Examination, 2Addenbrooke’s Cognitive Examination – Revised, 3Free and Cued Selective Reminding Test, 4Serbian adaptation of the Wechsler Adult Intelligence Scale – Revised, 5Hooper Visual Organization Test, 6Stroop Color and Word Test, 7Digit Ordering Test. Source: Author’s calculation (** indicate p < 0.01, while * indicates p < 0.05).