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SphK1 facilitates autophagy, EMT factors, and focal adhesions pathway. (A, B) Western blot analysis of SphK1, LC3Ⅱ/Ⅰ, paxillin, p‐paxillin, MMP2, E‐cadherin, and vimentin in CRC cells. (*p < 0.05 vs. NC‐RKO group, *p < 0.05 vs. NC‐HT29. (C) Western blot revealing LC3, paxillin, and p‐paxillin after 3MA treatment (10 mM, 24 h) in SphK1(+)‐HT29. (*p < 0.05 vs. NC‐HT29 group, SphK1(+)‐HT29 group or NC‐HT29 group +3MA). Data are shown as the mean ± SD of three replicates.
