TABLE 1.
The baseline and demographic characteristics of total cohort and different comparison patterns
| All | Comparison pattern 1 | Comparison pattern 2 | Comparison pattern 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (N = 15,836) | Chemotherapy (N = 9190) | Chemotherapy plus PTR (N = 325) | p | Chemoradiotherapy (N = 636) | Chemoradiotherapy plus PTR (N = 63) | p | No treatment (N = 5,231) | PTR only (N = 172) | p | |
| Age | 67 (59–75) | 66 (58–73) | 65 (58–71) | 0.107 | 64 (57–72) | 62 (57–68) | 0.12 | 71 (62–79) | 70 (62–78) | 0.174 |
| Female | 7419 (46.8) | 4211 (45.8) | 142 (43.7) | 0.449 | 284 (44.7) | 34 (54) | 0.157 | 2552 (48.8) | 97 (56.4) | 0.05 |
| Race | ||||||||||
| White | 12,549 (79.2) | 7432 (80.9) | 259 (79.7) | 0.064 | 492 (77.4) | 54 (85.7) | 0.06 | 3998 (76.4) | 143 (83.1) | 0.121 |
| Black | 2097 (13.2) | 1140 (12.4) | 34 (10.5) | 86 (13.5) | 2 (3.2) | 786 (15) | 19 (11) | |||
| Other | 1190 (7.5) | 618 (6.7) | 32 (9.8) | 58 (9.1) | 7 (11.1) | 447 (8.5) | 10 (5.8) | |||
| Grade | ||||||||||
| I | 280 (1.8) | 131 (1.4) | 17 (5.2) | <0.001 | 17 (2.7) | 3 (4.8) | <0.001 | 94 (1.8) | 16 (9.3) | <0.001 |
| II | 1612 (10.2) | 870 (9.5) | 124 (38.2) | 66 (10.4) | 27 (42.9) | 439 (8.4) | 72 (41.9) | |||
| III | 1842 (11.6) | 972 (10.6) | 129 (39.7) | 77 (12.1) | 21 (33.3) | 558 (10.7) | 59 (34.3) | |||
| IV | 65 (0.4) | 34 (0.4) | 1 (0.3) | 6 (0.9) | 0 (0) | 19 (0.4) | 3 (1.7) | |||
| Unknown | 12,037 (76) | 7183 (78.2) | 54 (16.6) | 470 (73.9) | 12 (19) | 4121 (78.8) | 22 (12.8) | |||
| T stage | ||||||||||
| 1 | 750 (4.7) | 424 (4.6) | 20 (6.2) | <0.001 | 23 (3.6) | 5 (7.9) | 0.001 | 251 (4.8) | 14 (8.1) | <0.001 |
| 2 | 4951 (31.3) | 2895 (31.5) | 151 (46.5) | 182 (28.6) | 27 (42.9) | 1575 (30.1) | 61 (35.5) | |||
| 3 | 4701 (29.7) | 2868 (31.2) | 109 (33.5) | 156 (24.5) | 22 (34.9) | 1437 (27.5) | 62 (36) | |||
| 4 | 2423 (15.3) | 1468 (16.0) | 31 (9.5) | 146 (23) | 7 (11.1) | 712 (13.6) | 20 (11.2) | |||
| Unknown | 3011 (19) | 1535 (16.7) | 14 (4.3) | 129 (20.3) | 2 (3.2) | 1256 (24) | 15 (8.7) | |||
| N stage | ||||||||||
| 0 | 322 (2) | 124 (1.3) | 66 (20.3) | <0.001 | 17 (2.7) | 16 (25.4) | <0.001 | 63 (1.2) | 34 (19.8) | <0.001 |
| 1 | 332 (2.1) | 95 (1.0) | 103 (31.7) | 9 (1.4) | 19 (30.2) | 52 (1) | 53 (30.8) | |||
| 2 | 168 (1.1) | 3 (0.0) | 93 (28.6) | 0 (0) | 17 (27) | 5 (0.1) | 49 (28.5) | |||
| Unknown | 15014 (94.8) | 8968 (97.6) | 63 (19.4) | 610 (95.9) | 11 (17.5) | 5111 (97.7) | 36 (20.9) | |||
| Tumor location | ||||||||||
| Head | 5574 (35.2) | 3109 (33.8) | 183 (56.3) | <0.001 | 248 (39) | 38 (60.3) | 0.001 | 1829 (35) | 94 (54.7) | <0.001 |
| Bodytail | 5913 (37.3) | 3.656 (39.8) | 110 (33.8) | 220 (34.6) | 19 (30.2) | 1787 (34.2) | 54 (31.4) | |||
| Overlapping | 1470 (9.3) | 910 (9.9) | 17 (5.2) | 52 (8.2) | 5 (7.9) | 465 (8.9) | 8 (4.7) | |||
| Other | 2879 (18.2) | 1515 (16.5) | 15 (4.6) | 116 (18.2) | 1 (1.6) | 1150 (22) | 16 (9.3) | |||
| Msite bone | 1133 (7.2) | 509 (5.5) | 6 (1.8) | 0.004 | 209 (32.9) | 3 (4.8) | <0.001 | 293 (5.6) | 6 (3.5) | 0.233 |
| Msite brain | 102 (0.6) | 29 (0.3) | 0 (0) | 0.311 | 25 (3.9) | 0 (0) | 0.109 | 28 (0.5) | 0 (0) | 0.336 |
| Msite liver | 12,151 (76.7) | 7265 (79.1) | 185 (56.9) | <0.001 | 375 (59) | 24 (38.1) | 0.001 | 4072 (77.8) | 90 (52.3) | <0.001 |
| Msite lung | 3107 (19.6) | 1816 (19.8) | 31 (9.5) | <0.001 | 158 (24.8) | 5 (7.9) | 0.002 | 1021 (19.5) | 20 (11.6) | 0.01 |
| Msite number | ||||||||||
| 0 | 2345 (14.8) | 1226 (13.3) | 114 (35.1) | <0.001 | 125 (19.7) | 32 (50.8) | <0.001 | 762 (14..6) | 65 (37.8) | <0.001 |
| 1 | 10,840 (68.5) | 6473 (70.4) | 200 (61.5) | 312 (49.1) | 30 (47.6) | 3620 (69.2) | 98 (57) | |||
| 2 | 2314 (14.6) | 1332 (14.5) | 11 (3.4) | 144 (22.6) | 1 (1.6) | 755 (14.4) | 9 (5.2) | |||
| 3 | 323 (2) | 154 (1.7) | 0 (0) | 53 (8.3) | 0 (0) | 92 (1.8) | 0 (0) | |||
| 4 | 14 (0.1) | 5 (0.1) | 0 (0) | 2 (0.3) | 0 (0) | 2 (0) | 0 (0) | |||
| Insurance status | ||||||||||
| Insured | 15,201 (96) | 8874 (96.6) | 316 (97.2) | 0.806 | 610 (95.9) | 60 (95.2) | 0.967 | 4971 (95) | 165 (95.9) | 0.79 |
| Uninsured | 421 (2.7) | 215 (2.3) | 6 (1.8) | 17 (2.7) | 2 (3.2) | 163 (3.1) | 5 (2.9) | |||
| Unknown | 214 (1.4) | 101 (1.1) | 3 (0.9) | 1.4 (9) | 1 (1.6) | 97 (1.9) | 2 (1.2) | |||
| Married | 9056 (57.2) | 5725 (62.3) | 226 (69.5) | 0.008 | 373 (58.6) | 38 (60.3) | 0.797 | 2.472 (47.3) | 105 (61) | <0.001 |
| Chemotherapy | 10,214 (64.5) | \ | \ | \ | \ | \ | \ | |||
| Radiotherapy | 918 (5.8) | \ | \ | \ | \ | \ | \ | |||
| PTR | 562 (3.5) | \ | \ | \ | \ | \ | \ | |||
| Distant/reginal site resection | 963 (6.1) | 421 (4.6) | 110 (33.8) | <0.001 | 54 (8.5) | 24 (38.1) | <0.001 | 272 (5.2) | 66 (38.4) | <0.001 |
Abbreviations: Msite, metastatic site; PTR, primary tumor resection.