TABLE 2.

Risk factors of progression during the 72‐week follow‐up in multivariate Cox regression analysis

Variable	HR (95% CI)	p value
Age	1.02 (1.01–1.03)	<0.001
Man	1.06 (0.87–1.29)	0.584
Smoker	1.42 (1.03–1.94)	0.030
Ex‐smoker (1–5 years ago)	1.53 (1.13–2.06)	0.006
Ex‐smoker (6–10 years ago)	0.77 (0.43–1.38)	0.379
Ex‐smoker (>10 years ago)	1.00 (0.78–1.28)	0.992
Metastasis (>1 location)	1.27 (1.06–1.53)	0.011
p.T790 M Mutation	1.38 (1.02–1.87)	0.038
Ex19del	2.12 (1.67–2.70)	<0.001
L858R	1.68 (1.27–2.22)	<0.001

Abbreviations: CI, confidence interval; HR, hazard ratio.