Fig. 15.

a The mechanism of action of ATTEC molecules. The ATTEC molecule interacts with the LC3 protein, and the formed complex is isolated in the cell membrane to form autophagosomes and finally undergo autophagic degradation in the lysosomes. b The structures of two hit compounds 10O5 and 8F20 and other identified effective linker compounds AN1 and AN2. The dotted ovals represent the chemical groups that may have protein-compound interactions during screening, and the red groups indicate the SMM label used for the nucleophile-isocyanate reaction