Table 2.

Association between circulating endothelial EVs and clinical variables by repeated measures correlation

EV population	Clinical Variable	r	95% CI	p
Endothelial	HbA1c	0.040	-0.072, 0.164	0.44
	Mean CGM Glucose	0.091	-0.006, 0.186	0.06
	% TIR (63-140mg/dl)	-0.005	-0.129, 0.118	0.94
	% TAR( >140mg/dl)	0.064	-0.060, 0.187	0.31
	% TBR (<63mg/dl)	-0.116	-0.236, 0.008	0.07
	Glucose CV	-0.012	-0.135, 0.112	0.85
	Glucose SD	0.054	-0.070, 0.177	0.39
	MAGE	0.129	0.005, 0.248	0.04
	SBP	0.082	-0.035, 0.196	0.17
	DBP	0.075	-0.043, 0.189	0.21
Platelet	HbA1c	0.009	-0.107, 0.126	0.88
	Mean CGM Glucose	-0.111	-0.231, 0.013	0.08
	% TIR (63-140mg/dl)	0.159	0.035, 0.276	0.01
	% TAR( >140mg/dl)	-0.138	-0.257, -0.014	0.03
	% TBR (<63mg/dl)	-0.055	-0.178, 0.068	0.38
	Glucose CV	-0.109	-0.229, 0.015	0.08
	Glucose SD	-0.147	-0.267, -0.025	0.02
	MAGE	-0.152	-0.271, -0.029	0.01
	SBP	0.051	-0.066, 0.167	0.39
	DBP	0.099	-0.017, 0.210	0.09
Leukocyte	HbA1c	0.001	-0.116, 0.116	0.99
	Mean CGM Glucose	0.003	-0.120, 0.127	0.95
	% TIR (63-140mg/dl)	0.007	-0.116, 0.131	0.91
	% TAR( >140mg/dl)	0.003	-0.121, 0.127	0.96
	% TBR (<63mg/dl)	-0.030	-0.154, 0.093	0.62
	Glucose CV	0.008	-0.115, 0.132	0.89
	Glucose SD	0.013	-0.110, 0.137	0.83
	MAGE	0.001	-0.124, 0.123	0.99
	SBP	0.179	0.064, 0.289	0.002
	DBP	0.200	0.093, 0.315	0.001

Significant relationships are bolded

CGM continuous glucose monitoring, TIR time in range, TAR time above range, TBR time below range, CV coefficient of variation, SD standard deviation, MAGE mean amplitude of glycemic excursion, SBP systolic blood pressure, DBP diastolic blood pressure