Table 2.

Correlation analysis between MARCH3 and related genes and markers of immune cells in HCC by GEPIA analysis

Description	Gene markers	MARCH3
		Correlation	P-value
CD8 + T cell	CD8A	0.31	9.3e−10
	CD8B	0.25	7.2e−07
T cell	CD3D	0.38	5.2e−14
	CD3E	0.42	1.9e−17
	CD2	0.42	2.1e−17
B cell	CD19	0.32	3.4e−10
	CD79A	0.39	4.1e−15
Monocyte	CD86	0.46	4.4e−21
	CSF1R	0.38	2e−14
TAM	CCL2	0.16	0.0015
	CD68	0.24	2.4e−06
	IL10	0.34	1.7e−11
M1 Macrophage	NOS2	0.13	0.012
	IRF5	0.33	4e−11
	PTGS2	0.47	5.5e−22
M2 Macrophage	CD163	0.16	0.0017
	VSIG4	0.22	1.3e−05
	MS4A4A	0.26	3.4e−07
Neutrophils	CEACAM8	0.13	0.0099
	ITGAM	0.34	2.1e−11
	CCR7	0.41	2e−16
Natural killer cell	KIR2DL1	0.022	0.67
	KIR2DL3	0.12	0.023
	KIR2DL4	0.14	0.0083
	KIR3DL1	-0.093	0.075
	KIR3DL2	0.22	2.9e−05
	KIR3DL3	0.15	0.004
	KIR2DS4	0.0033	0.95
Dendritic cell	HLA-DPB1	0.38	2.2e−14
	HLA-DQB1	0.20	1e−04
	HLA-DRA	0.34	1.1e−11
	HLA-DPA1	0.35	3.3e−12
	BDCA-1(CD1C)	0.45	1.5e−19
	BDCA-4(NRP1)	0.27	1.8e−07
	CD11c (ITGAX)	0.45	6.2e−20
Th1	T-bet (TBX21)	0.21	3.6e−05
	STAT4	0.45	3.9e−20
	STAT1	0.41	1.2e−16
	IFN-γ (IFNG)	0.18	0.00036
	TNF-α (TNF)	0.39	7.1e−15
Th2	GATA3	0.46	1.1e−20
	STAT6	0.14	0.0062
	STAT5A	0.34	2.7e−11
	IL13	0.17	0.00077
Tfh	BCL6	0.067	0.2
	IL21	0.14	0.0055
Th17	STAT3	0.3	3.5e−09
	IL17A	0.093	0.074
Treg	FOXP3	0.12	0.018
	CCR8	0.46	1.6e−20
	STAT5B	0.15	0.0052
	TGFβ (TGFB1)	0.57	4.7e−33
T cell exhaustion	PD-1 (PDCD1)	0.43	2.3e−18
	CTLA4	0.42	8.6e−17
	LAG3	0.18	0.00056
	TIM-3 (HAVCR2)	0.49	1.8e−23
	GZMB	0.068	0.19

^*P < 0.01, **P < 0.001, ***P < 0.0001. The result of P < 0.05 means statistical significance