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. 2021 Sep 6;23:234. doi: 10.1186/s13075-021-02592-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Dysregulated PPAR-associated gene and protein expression in TβRII∆k-fib mouse (TG) skin, lung, explanted fibroblasts and aortic smooth muscle cells. A Illumina gene array expression across tissues and explanted cells from TG compared to wildtype (WT) littermates. Bold- downregulated in TG; not bold- upregulated in TG; normal font- significant, P < 0.05; italicised font- trend only, P < 0.10; FB = fibroblast explant culture; aSMC = aortic smooth muscle cell explant culture, n = 3 all groups. B Representative immunohistochemical stains for PPAR subtypes in WT and TG, low power (× 10) and high power (× 20) including IgG control (n ≥ 3 each group). C Number of positive nuclei per high power field (HPF) in TG and WT immunohistochemical stains for each PPAR subtype