Table 1.

Pharmacokinetic parameters of DOX in control and ADI groups after single intravenous administration of DOX (7 mg/kg) ($\overline{X}$ ± SD, n = 6)

Parameters	Control	ADI
t1/2α (h)	0.074 ± 0.005	0.089 ± 0.017**
t1/2β (h)	2.734 ± 1.385	2.638 ± 1.108
V1 (L/kg)	0.099 ± 0.026	0.028 ± 0.011**
CL (L/h/kg)	0.37 ± 0.15	0.099 ± 0.048*
AUC0-t (mg/L*h)	20.21 ± 11.22	76.50 ± 34.89**
K10 (1/h)	3.91 ± 1.67	3.68 ± 1.69
K12 (1/h)	5.26 ± 2.05	4.27 ± 0.73
K21 (1/h)	0.77 ± 0.49	0.65 ± 0.48

Data are presented as mean ± SD (n = 6). *P < 0.05, **P < 0.01 versus control group

t_½α, half-life of distribution; t_½β, half-life of elimination; V₁, apparent volume of distribution in central compartment; CL, clearance; AUC_0-t, area under plasma drug concentration-time curve; K₁₀, elimination rate constant of drug from compartment 1; K₁₂, rate constant for movement of drug from compartment 1 to compartment 2; K₂₁, rate constant for movement of drug from compartment 2 to compartment 1