Table 2.

Pharmacokinetic parameters of DOXol in control and ADI groups after single intravenous administration of DOX (7 mg/kg) ($\overline{X}$ ± SD, n = 6)

Parameters	Control	ADI
AUC0-t (mg/L*h)	5.62 ± 2.23	16.41 ± 2.91**
MRT0-t (h)	2.40 ± 0.32	5.33 ± 1.31**
t1/2z (h)	2.09 ± 0.98	4.99 ± 0.95**
Tmax (h)	0.33 ± 0.001	0.33 ± 0.001
CLz/F (L/h/kg)	1.33 ± 0.57	0.43 ± 0.08
Vz/F (L/kg)	4.43 ± 3.86	3.13 ± 0.98
Cmax (mg/L)	2.41 ± 1.04	8.34 ± 3.90**

Data are presented as mean ± SD (n = 6). **P < 0.01 versus control group

AUC_0-t, area under plasma drug concentration-time curve; MRT_0-t, mean residence time; t_1/2z, half-life of elimination; T_max, peak time; CLz, clearance; Vz, apparent volume of distribution; C_max, maximum (peak) plasma drug concentration