Table 2.
The effects of sex and CKD on ex vivo heart weights, tibia length, and basal coronary flow
| Parameter (unit) | Male | Female | p-value | |||
|---|---|---|---|---|---|---|
| Sham | CKD | Sham | CKD | CKD vs. sham | Female vs. male | |
| Body weight (g) | 488 ± 8 | 451 ± 7* | 268 ± 4# | 254 ± 3*# | < 0.001 | < 0.001 |
| Tibia length (cm) | 4.27 ± 0.03 | 4.18 ± 0.06* | 3.82 ± 0.04# | 3.73 ± 0.03*# | 0.049 | < 0.001 |
| Heart weight (mg) | 2450 ± 68 | 2541 ± 63 | 1476 ± 34# | 1536 ± 32# | 0.210 | < 0.001 |
| LV weight (mg) | 1319 ± 34 | 1434 ± 49* | 900 ± 33# | 1023 ± 34*# | 0.005 | < 0.001 |
| CF10' (mL/min) | 17.5 ± 0.8 | 17.4 ± 1.0 | 11.0 ± 0.4# | 12.1 ± 0.4# | 0.720 | < 0.001 |
| Kidney weight (mg) | 1330 ± 43 | 1809 ± 79 | 989 ± 50# | 1189 ± 75 | N/A | < 0.001 |
| Lung weight (mg) | 1596 ± 55 | 1765 ± 67 | 1508 ± 36# | 1464 ± 37# | 0.242 | < 0.001 |
Values are mean ± SEM, n = 30–55 for body weight, heart weight and CF10’ (sham male: n = 35, CKD male: n = 31, sham female: n = 30, and CKD female: n = 55), and n = 13–19 for tibia length, LV weight, kidney weight and lung weight (sham male: n = 19, CKD male: n = 13, sham female: n = 18, and CKD female: n = 18), *p < 0.05, CKD vs. sham-operated groups, #p < 0.05, females vs. males, respectively, p-values refer to two-way ANOVA (Holm–Sidak post hoc test). CF10' coronary flow collected at the 10th minute or perfusion protocol, CKD chronic kidney disease, LV left ventricular