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. 2021 Aug 23;12:718983. doi: 10.3389/fphys.2021.718983

FIGURE 4.

FIGURE 4

Current proposal for the evolutionary history of Lipocalin in chordates. Evolutionary path suggested for Lipocalin duplication and diversification in chordates. Six Lipocalins evolved during fish evolution, while at least nine novel Lipocalins evolved in terrestrial vertebrates.