Figure 6.

Schematic illustration of large‐sized graphene oxide enhancing DC–T‐cell synaptic contact and magnifying DC vaccine efficiency against SARS‐CoV‐2. a) The high binding affinity of L‐GOs with DC membrane promoted DC–T‐cell clustering. b) L‐GOs enhance DC–T‐cell synapse formation via cytoskeleton‐dependent membrane‐positioning of integrin ICAM‐1. c) The footpad‐injected DC vaccines prime T cells in PLN. d) SARS‐CoV‐2 spike‐1‐specific cytotoxic T cells and anti‐SARS‐CoV‐2 spike 1 antibodies corporately clear the infections.