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One‐week serological kinetics in ICU patients. In panels (A‐C), ICU patients showed a significant increase (P‐value of ****P < .0001 and P = .025) in antibody titre throughout seven days (days: 0, 3 and 7). In panel (D), the anti‐ pneumococcal (Pn14) antibody titre did not present any change over time (P = .3). Results are expressed as median with interquartile range and the Kruskal‐Wallis test was used to compare the three groups. Samples were analysed in duplicate
