FIGURE 2.

ADAMTS13 conformation in 53 critically ill COVID‐19 patients at ICU admission. Plasma samples of 53 COVID‐19 patients at admission were added to wells coated with the anti‐ADAMTS13 antibody 1C4 before and after incubation with the anti‐CUB1 antibody 17G2 inducing an open conformation in ADAMTS13. If ADAMTS13 was not captured by 1C4, the conformation of ADAMTS13 is closed (conformation index ≤0.5). If ADAMTS13 was captured by 1C4, the conformation of ADAMTS13 is open (conformation index >0.5). All patients exhibited a closed ADAMTS13 conformation, which was induced open after addition of the anti‐CUB1 antibody 17G2