TABLE 1.
Summary of drugs with EC50 < 1 µM, fup*PK/EC50 > 1, and fup < 0.01
| Drugs in PK with EC50 < 1 µM | Drugs in PK with fup*PK/EC50 > 1 | Drugs in PK with fup < 0.01 |
|---|---|---|
| Amodiaquine | Atazanavir | Azilsartan |
| Astemizole | Chloroquine | Ciclesonide |
| Atazanavir | Favipiravir | Clofazimine |
| Bromhexine | Nafamostat | Dolutegravir |
| Camostat | Naquotinib | Droloxifene |
| Chloroquine | Nitazoxanide | Eltrombopag |
| Clofazimine | Remdesivir | Indomethacin |
| Cyclosporine | Tetrandrine | Ivacaftor |
| Dacomitinib | Lopinavir | |
| Digitoxin | Lusutrombopag | |
| Digoxin | Midostaurin | |
| Hanfangchin A (Tetrandrine) | Nitazoxanide | |
| Hexachlorophene | Osimertinib mesylate | |
| Hydroxychloroquine | Pazopanib | |
| Nafamostat | Pimozide | |
| Naquotinib | Pioglitazone | |
| Niclosamide | Piperaquine | |
| Pioglitazone | Tetrandrine | |
| Pyronaridine | Thioridazine | |
| Remdesivir | Tipranavir | |
| Tetrandrine | Toremifene |
Abbreviations: EC50, the drug concentration that inhibits 50% of the virus; fup, unbound fraction in plasma; PK, pharmacokinetic.