TABLE 3.

Quality appraisal of studies included in the meta‐analysis using Jadad scale assessment

Study	Random allocation	Concealment schemes	Blinding	Withdrawals and drop‐out	Total score	Interpretation
Castillo ME et al. 24 2020	2	1	0	1	4	Moderate quality
Murai IH et al. 29 2020	2	2	2	1	7	High quality

Note: Points were determined as follows: (1) random allocation: computer‐generated random numbers, 2 points; not described, 1 point; inappropriate method, 0 point; (2) allocation concealment: central randomization, sealed envelopes or similar, 2 points; not described, 1 point; inappropriate or unused, 0 point; (3) blindness: identical placebo tablets or similar, 2 point; inadequate or not described, 1 point; inappropriate or no double blinding, 0 point; and (4) withdrawals and drop‐outs: numbers and reasons are described, 1 point; not described, 0 point. The Jadad scale score ranges from 1 to 7; higher score indicates better RCT quality. If a study had a modified Jadad score >4 points, it was considered to be of high quality; if the score was 3–4 points, it was moderate quality; and if the score was <3 points, it was low quality.