Figure 1.

Overview of proposed approach for engineering potent, broadly neutralizing multivalent nanobodies. A nanobody (VHH‐72) targeting an epitope that is conserved between SARS‐CoV and SARS‐CoV‐2 was engineered to increase its neutralization activity toward the SARS‐CoV‐2 virus. The valency of VHH‐72 was systematically increased by incorporating it into bivalent, tetravalent, and hexavalent Fc‐fusion constructs, and their ability to neutralize highly transmissible SARS‐CoV‐2 variants was analyzed.