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. 2021 Sep 9;224(6):989–994. doi: 10.1093/infdis/jiab368

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© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Entry efficiency and neutralization sensitivity of B.1.617 mutant pseudotyped viruses following mRNA vaccination A, Surface representation of the spike protein in open formation with neutralizing antibody H4 (pink spheres, Protein Data Bank 7L58, [8] ) bound to 1 monomer of the spike protein. Residues L452 and E484 are indicated with red and green spheres, respectively. Ribbon is a representation of the interaction between the neutralizing antibody H4 and the receptor-binding domain of a spike monomer. Neutralization by (B) first-dose and (C) second-dose mRNA vaccine-elicited sera against wild type (WT) and mutant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike pseudotyped viruses. Reciprocal geometric mean titer shown with 95% confidence interval. *P < .05, ***P < .001, ****P < .0001. D, Virus infectivity of pseudotyped virus (PV) bearing indicated spike mutations. PVs were generated in 293T cells and used to infect HOS cells transduced with ACE2 and TMPRSS2. Input virus was normalized for protein expression. Data are technical triplicates and mean with SE is plotted. Data are representative of 2 independent experiments.