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. 2021 Jul 19;224(9):1489–1499. doi: 10.1093/infdis/jiab375

Figure 2.

Figure 2.

Modeled severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody kinetics. A mathematical model of SARS-CoV-2 antibody kinetics was simultaneously fitted to data from 7 studies of SARS-CoV-2 [6-11] and 1 study of severe acute respiratory syndrome coronavirus (SARS-CoV-1) [12]. A, top row, Examples of the model fit to the data for 1 individual from each study. Data are represented as points, posterior median model prediction as lines, and 95% credible intervals as shaded areas. B, middle and bottom rows, Model-predicted duration of antibodies within the first 2 years following infection. Antibody levels are shown relative to the expected antibody level at day 14 post–symptom onset. Each point represents the prediction from an individual at 6, 12, 18, and 24 months post–symptom onset. The median predictions for each of the 8 studies are presented as lines. Abbreviations: IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; RBD, receptor-binding domain; SARS-CoV-1, severe acute respiratory syndrome coronavirus.