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. 2021 Sep 3;9(9):e002336. doi: 10.1136/jitc-2021-002336

Figure 5.

Figure 5

Prognostic subclasses of POL and DDR pathway gene alterations. (A, B) Kaplan-Meier estimates of overall survival in the TCGA cohort showing distinct prognostic subclasses defined by POL and DDR pathway gene mutational status. (C) Kaplan-Meier estimates of overall survival in the TCGA cohort comparing patients with varying number of defective DDR pathway genes. (D) Kaplan-Meier estimates of overall survival in the TCGA cohort comparing patients with different types of DDR pathway gene alterations (DDR_loss, missense, DDR+ patients with both loss of function and otherwise missense mutations; DDR_loss only, DDR+ patients with only loss of function mutations; DDR_missense only, DDR+ patients with only missense mutations that are not nonsense mutations; DDR−, patients with no DDR alterations). DDR, DNA damage repair; TCGA, The Cancer Genome Atlas.