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. 2021 Sep 3;9(9):e002876. doi: 10.1136/jitc-2021-002876

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Characterization of orthotopic pancreatic cancer isograft mouse models. (A) RNA-seq of pancreatic cancer cell-derived graft (CDG) recapitulates the Moffitt and Bailey human pathology; (B) Kaplen-Meier survival analysis of C57BL/6J mice bearing the indicated pancreatic cancer subtypes; (C) comparative flow cytometry analysis of immune infiltrating components of cancer tissues from CDG bearing mouse models. T cells, CD45⁺CD3⁺; Teffs, CD45⁺CD8⁺CD3⁺; Tregs, CD45⁺CD3⁺CD4⁺CD25⁺FOXP3⁺; monocytes, CD45⁺CD11b⁺Ly6C⁺; B cells, CD45⁺CD19⁺; NK cells, CD45⁺CD49b⁺; granulocytes, CD45⁺CD11b⁺Ly6G⁺. NK, natural killer.