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. 2021 Sep 3;9(9):e002876. doi: 10.1136/jitc-2021-002876

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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IMO-2125 (intratumorally) promotes immune system activation and lymph nodes volume increase. (A) Lymph node volume of Tumor Draining Lymph Nodes (TDLNs, (inguinal and axillary) of the both animal flanks. Lymph nodes were isolated from the both animal flanks of the indicated tumor-bearing mice models. Lymph nodes (inguinal and axillary) average size and Standard Deviation (DS) are plotted. Statistical difference is calculated with a paired two-tailed t-test; Flow cytometry analysis of the indicated immune cell populations from smashed lymph nodes of (B) locally treated (R) and (C) untreated (L) FC1242 and DT34313 tumor-bearing mouse models; dendritic cells were gated as CD11c⁺MHCII⁺ cells. Statistical differences were analyzed with two-way analysis of variance. All data represent average ±SEM (n=4 per group) (*p<0.05, **p<0.01, ***p<0.001).