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. 2021 Aug 20;12:708835. doi: 10.3389/fgene.2021.708835

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Copyright © 2021 Lu, Sha, Silva, Colaprico, Sun, Ban, Wang, Lehmann and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multiple ligand receptor interactions between luminal epithelial cells and myoepithelial cells. (A) UMAP plot shows distinct cell populations in five TNBC tumors. (B) Image shows unique ligand (red) receptor (black) interactions between myoepithelial and luminal breast cells. (C) Circos plots show the top interactions and by direction between myoepithelial and luminal cells. LR interactions are colored by interaction strength (rank sum) and line thickness represents the frequency of interaction across the five tumors.