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. 2021 Sep 7;28(7-8):779–790. doi: 10.3727/096504021X16161478258040

Figure 3.

Figure 3

Effect of BX795 on apoptosis pathway. Treatment with BX795 at the concentrations of 1 and 10 μM significantly increased Bax and p53 mRNA expression (A, B) and reduced Bcl-2 mRNA expression (C) in U-87 cells compared to the control group evaluated by real-time quantitative polymerase chain reaction (RT-qPCR). Moreover, Western blot analysis confirmed an increase in Bax (D) and p53 expression (E) and a reduction in Bcl-2 (F). Data are representative of at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 versus control.