Table 2.
Adverse Events of 70 mCRC Patients
| Adverse Events | Grade 0 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Study [n (%)] |
Control [n (%)] |
Study [n (%)] |
Control [n (%)] |
Study [n (%)] |
Control [n (%)] |
Study [n (%)] |
Control [n (%)] |
Study [n (%)] |
Control [n (%)] |
|
| Gastrointestinal toxicities | ||||||||||
| Diarrhea | 193 (94.6) | 170 (85.4) | 7 (3.4) | 17 (8.5) | 4 (2.0) | 8 (4.0) | 0 | 4 (2.0) | 0 | 0 |
| Nausea | 149 (73.0) | 119 (66.5) | 48 (23.5) | 62 (31.2) | 7 (3.4) | 16 (8.0) | 0 | 2 (1.0) | 0 | 0 |
| Vomiting | 181 (88.7) | 168 (48.1) | 15 (7.4) | 15 (7.5) | 8 (3.9) | 13 (6.5) | 0 | 3 (1.5) | 0 | 0 |
| Hepatic toxicities | ||||||||||
| Increased SGOT level | 168 (82.4) | 173 (86.9) | 31 (15.2) | 21 (10.6) | 5 (2.5) | 3 (1.5) | 0 | 1 (0.5) | 0 | 1 (0.5) |
| Increased SGPT level | 175 (85.8) | 173 (86.9) | 27 (13.2) | 24 (12.1) | 2 (1.0) | 0 | 0 | 1 (0.5) | 0 | 1 (0.5) |
| Hematologic toxicities | ||||||||||
| Leukopenia | 152 (74.5) | 126 (63.3) | 41 (20.1) | 47 (23.6) | 11 (5.4) | 25 (12.6) | 0 | 1 (0.5) | 0 | 0 |
| Anemia | 44 (21.6) | 68 (34.2) | 115 (56.4) | 98 (49.2) | 45 (22.1) | 33 (16.6) | 0 | 0 | 0 | 0 |
Abbreviations: SGOT, serum glutamic oxaloacetic transaminase; SGPT, serum glutamic pyruvic transaminase.