Table 4.
Spearman correlation analysis between glucose metabolism parameters and HBV-related biological and serum parameters (n = 110).
| Variable | Glucose metabolism (1 = NGT, 2 = IGR, and 3 = DM) | FPG (mmol/L) | FINS (mU/L) | HOMA-IR (mU ∗ mmol/L2) | HOMA-β (mU/mmol) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| r | P | r | P | r | P | r | P | r | P | |
| Cirrhosis(1 = without, 2 = with) | 0.191 | 0.046 | 0.322 | 0.001 | 0.328 | <0.0001 | ||||
| HBeAg (1 = negative, 2 = positive) | −0.330 | <0.0001 | −0.268 | 0.005 | ||||||
| HBsAg | −0.350 | <0.0001 | −0.334 | <0.0001 | 0.200 | 0.036 | ||||
| HBsAb | −0.270 | 0.004 | −0.199 | 0.037 | −0.281 | 0.003 | ||||
| HBeAg | −0.321 | 0.001 | −0.232 | 0.015 | ||||||
| HBeAb | 0.396 | <0.0001 | 0.333 | <0.0001 | 0.240 | 0.012 | ||||
| HBcAb | −0.205 | 0.032 | ||||||||
| HBVDNA | −0.202 | 0.034 | −0.190 | 0.047 | ||||||
| ALP | 0.247 | 0.009 | 0.286 | 0.002 | −0.361 | <0.0001 | ||||
| GGT | 0.354 | <0.0001 | 0.293 | 0.002 | ||||||
| LSM | 0.260 | 0.006 | 0.272 | 0.004 | 0.230 | 0.015 | 0.306 | <0.0001 | ||
ALP, alkaline phosphatase; FINS, fasting serum insulin; DM, diabetes mellitus; FPG, fasting plasma glucose; GGT, gamma glutamyl transferase; HbA1c, glycosylated hemoglobin; HBcAb, hepatitis B core antibody; HBeAb, hepatitis B envelope antibody; HBeAg, hepatitis B envelope antigen; HBsAb, hepatitis B surface antibody; HBsAg, hepatitis B surface antigen; HBVDNA, hepatitis B viral nucleic acid load; HOMA-β, homeostasis model assessment of β cells; HOMA-IR, homeostasis model assessment of insulin resistance; IGR, impaired glucose regulation; LSM, liver stiffness measurement; NGT, normal glucose tolerance.