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. 2021 Aug 11;49(15):8714–8731. doi: 10.1093/nar/gkab685

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — The level of MMB-TIs is increased in tumors from multiple primary tumor sites. (A) Number of MMBSearch calls per 100 million reads quantified for paired tumor (red) and non-tumor (blue) samples. WGS data was obtained from 71 total TCGA cancer cases. Asterisks indicate statistically significant difference in the level of MMB-TIs between tumor and non-tumor for each cancer site (P-value < 0.05) calculated by ratio paired t-test. NS = no significant difference. Cancer primary sites are as follows: Ovarian cancer (OVA) (n = 14), lung adenocarcinoma (LUAD) (n = 19), colon adenocarcinoma (COAD) (n = 6), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) (n = 5), breast invasive carcinoma (BRCA) (n = 10), prostate adenocarcinoma (PRAD) (n = 9), and glioblastoma multiforme (GBM) (n = 8). Black lines indicate median values for each set. (B) Fold-increase in the amount of tumor versus non-tumor MMBSearch calls shown in (A). Each dot represents one cancer case (tumor compared to matched non-tumor). Black lines indicate mean fold-increase.