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. 2021 Aug 11;49(15):8714–8731. doi: 10.1093/nar/gkab685

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — MMB-TI events accumulate de novo in a Lung adenocarcinoma patient sample. (A) The number of MMBSearch calls per chromosome for lung tumor (BO13-UIBB-1654) and matched non-tumor (BO14-UIBB-1654) tissue samples. (B) Fold-increase of MMBSearch calls in tumor-specific calls compared to non-tumor-specific calls (for the counts shown in A) normalized to the total number of reads for each individual sample. (C) Analysis of all MMBSearch calls on Chromosome 1 in lung tumor from (A) (n = 414). Parameters for both samples were ≥3 reads per cluster, insertions that are ≥10 bp in length, and ≥80% identity between template and insertion. (D) Microhomology and microhomeology distribution for lung tumor-specific MMB-TI event junctions (n = 105) from Chromosome 1 (dataset shown in A (Chromosome 1) and C).