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. 2021 Aug 11;49(15):8714–8731. doi: 10.1093/nar/gkab685

Figure 6.

Figure 6.

MMB-TI initiates genomic rearrangements. (A) (i) MMB-TI event J2 found on q13.13 band of Chromosome 20 (Chr20) that is fused to the q11.2 band of Chromosome 5 (Chr5) (red vertical lines indicate positions). (ii) Alignment of J2 consensus to all reference templates. Insertion consists of 2 parts (orange and pink text) copied from two corresponding templates (light blue and green, respectively). Chromosome 20 sequence is shown in black text, and Chromosome 5 sequence is shown in navy. Microhomology used in each template switching event is underlined and highlighted in light green boxes. (iii) Schematic illustrating template switching events that lead to the formation of J2. Circled numbers indicate order of template switches. Boxed arrows indicate direction of synthesis, numbers above boxes indicate length of synthesis, and colors correspond to those in (i). (B) (i) MMB-TI events J5 and J6 found on q33.3 band of Chromosome 5. (ii) Alignment of the J5 rearrangement junction consensus to its reference components on Chromosome 5 and Chromosome 20. Microhomology at J5 is underlined and highlighted in light green boxes. Alignment of event J6 consensus to all reference templates. All labeling similar to (Ai). (iii) Schematic illustrating the structure of J5, its proximity to J6 (89bp), and the two template switching events that lead to the formation of J6. Circled numbers indicate order of template switches. Boxed arrows indicate direction of synthesis, numbers above boxes indicate length of synthesis, and colors correspond to those in i.