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. 2021 Aug 5;49(15):8743–8756. doi: 10.1093/nar/gkab652

Figure 7.

Figure 7.

Model of the eIF4G contribution to the REI-permissiveness of uORF1 of yeast GCN4. The fully intact RNA-binding ability of the eIF4G-RNA2 domain allows for a specific interaction with the RPE i during uORF1 translation, perhaps in co-operation with eIF3 (A), whereas the preserved post-termination eIF4G-4A contact enables timely resumption and processivity of traversing (B).