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. 2021 Jul 31;49(15):8520–8534. doi: 10.1093/nar/gkab638

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Case study of the application of CellCall in the TIME. (A) Circos plot of intercellular communication among immune cells in the NSCLC dataset (GSE139555). (B) Common tumor-specific intercellular communications in 10 TIME datasets. (C) Intercellular crosstalk from other immune cells to Mono/Macro cells in the TIME. (D) Sankey plot of seven common tumor-specific intercellular communications and downstream TFs. (E) Association of TF expression with patient survival in the TCGA pan-cancer data. (F) Kaplan–Meier curves of selected TFs. Statistical significance and hazard ratios were calculated using multivariate Cox regression.