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Structural comparison of GR binding to canonical GBS, pre-GBS, modified pre-GBS and TRE sites. (A) Structural overlay of GR bound to GBS (blue), 5mC-GBS (purple) and pre-GBS (green). Arg447 is involved in the base-specific hydrogen bonds (red dashed line) and van der Waals contacts (black dashed line) with TpG in GBS (B), methylated CpG in 5mC-GBS (C), unmodified pre-GBS (D), TpG in TRE (E) and the conserved 5mC–Arg–G triad as shown in MeCP2/DNA binding (PDB code: 3C2I) (F).
