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. 2021 Jul 30;49(15):8556–8572. doi: 10.1093/nar/gkab626

Figure 2.

Figure 2.

Down-regulated GPER1 and miR-339 in four different breast cancer subtypes. (A) 332 TSGs positively related to miR-339 regulation among the 383 downregulated TSGs. The green circle represents the number of 332 target genes positively related to miR-339, and orange circle represents 383 downregulated TSGs in breast cancer samples from TCGA database. (B) The 322 targeted genes of miR-339 associated to p53 pathway and pathways in cancer by KEGG pathway profiling. (C−F) GPER1, and miR-339 were both down-regulated in Luminal A (C, about 83.7% down-regulated, Correlation coefficient = 0.745), Luminal B (D, about 88.9% down-regulated, Correlation coefficient = 0.745), and TNBC (E, about 79.4% down-regulated, correlation coefficient = 0.808) breast cancer subtypes, except for the HER2-positive subgroup (F, only 42.8% down-regulated, correlation coefficient = 0.68) where they still exist a positive correlation between miR-339 and GPER1. TNBC means triple negative breast cancer subtype.