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. 2021 Jul 30;49(15):8556–8572. doi: 10.1093/nar/gkab626

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — MiR-339 acts as an inhibitor by using mouse xenograft breast cancer models. (A) MiR-339 inhibited tumour growth by activating GPER1 via measuring the volume of tumours in mice by days. The nude mice formed the first measurable tumour marked as d0, and then tumours in mice were measured in the next 4 weeks until sacrifice. (B, C) MiR-339 inhibits the tumour growth by measuring weight and volume, which was counteracted if knockdown GPER1. The weight (B), the tumour virtual size (C, Left panel), and the calculated tumour volume (C, Right panel) of tumours in the sacrificed mice. (D, E) The alteration of Ki67 staining within breast cancer cell from xenograft mouse models. Ki67 staining decreased with miR-339 expression and increased after knocking down GPER1 by microscope (D) and by image J software calculation (E). Data are presented as mean ± SD of experiments conducted in triplicate (one-Anova test, followed by Tukey's test). ****P < 0.0001, **P < 0.01, *P < 0.05.