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. 2021 Jul 30;49(15):8556–8572. doi: 10.1093/nar/gkab626

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — The model illustrated that how tumour suppressor gene GPER1 is silenced in breast cancer. In normal breast cell, NamiRNA miR-339 binds to the enhancer region colocalized with AGO2 to activate tumour suppressor gene GPER1, which protects the normal cell from transformation into malignant ones. However, when the expression of miR-339 is downregulated to reduce the enhancer activity , the corresponding TSG GPER1 would be silenced and failed to play its repressive functions on tumourigenesis.