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. 2021 Sep 2;16:2503–2513. doi: 10.2147/COPD.S321877

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© 2021 Che et al.

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RELMβ activates the phosphorylated p38 MAPK signaling pathway. (A-C) Western blotting results showed that stable overexpression of RELMβ in 16HBE cells could not induce the phosphorylation of ERK1/2, Akt, and SAPK/JNK. (D1, D2) Our Western blotting results showed that RELMβ overexpression could induce phosphorylated p38 MAPK expression. (E1, E2) When we knocked down RELMβ gene expression, phosphorylated p38 MAPK was still not activated even after stimulation with tobacco smoke extract. *p≤0.05.