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. 2021 Sep 2;218(11):e20210777. doi: 10.1084/jem.20210777

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© 2021 Xu et al.

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Figure 4. — Arkadia does not influence SFB-dependent Th17 cell differentiation or Th17 cell–mediated EAE. (A) Analysis of RORγt, FOXP3, and effector cytokine expression in T lymphocytes from small intestine lamina propria of mice colonized with SFB. Unpaired t test analysis for one experiment with five control littermates and five Arkadia mutant mice. (B) EAE disease score in control littermates and Arkadia mutant mice. Data are from one experiment with 10 mice per group. EAE clinical scores were analyzed by two-way ANOVA. (C) Statistical analysis of indicated cell populations at peak of EAE disease. Data were collected from six control littermates and five Arkadia mutant mice (independent experiments from B). Differences between experimental groups were determined by unpaired t test. Error bars represent SD. Black circle, control littermates; red triangle, Arkadia mutant mice. *, P < 0.05; **, P < 0.01; ***, P < 0.001.