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. 2021 Sep 6;12:5263. doi: 10.1038/s41467-021-25634-z

Fig. 9. A model depicting Wnt-driven, CRBN-dependent regulation of CK1α.

Fig. 9

Upon stimulation of Wnt signaling, CRBN is recruited to the β-Catenin destruction complex and targets CK1α for degradation, further promoting Wnt pathway activation.