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. 2021 Sep 6;6:113. doi: 10.1038/s41541-021-00376-7

Fig. 4. Allelic variations in IGHV1-2 genes impact CD4bs recognition and possibly BCR expression.

Fig. 4

a Amino acid sequence alignment of the seven annotated IGHV1-2 alleles. The IGHV1-2*02 allele is shown as the reference. The Kabat numbering scheme of the residues is shown. Residues highlighted in blue indicate the position of key residues in IGHV1-2 required for binding to the CD4bs. Residue position 66 is shown in green. b Of all the IMGT curated functional IGHV genes (n = 296), the majority of the genes utilize an arginine residue at position 66.