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. 2021 Sep 6;12:5262. doi: 10.1038/s41467-021-25618-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The circle represents TFE3 gene fusions in our TFE3-tRCC cohort. B Exons and function domains for TFE3 gene (top). Protein domains are color-coded and depicted. Mapping of breakpoints onto the three-dimensional structure of TFE3 protein (bottom). C Exons and functional domains of the TFE3 and fusion partner genes detected in our TFE3-tRCC cohort. TFE3-tRCC TFE3-translocation renal cell carcinoma, AD strong transcription activation domain, bHLH basic helix–loop–helix domain, LZ leucine zipper domain, RRM RNA-recognition motif, SREBF1 Sterol Regulatory Element Binding Transcription Factor 1, MAD2L2 mitotic spindle assembly checkpoint protein MAD2B, KH K homology domain, Znf zinc-finger domains.