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. 2021 Sep 6;12:5296. doi: 10.1038/s41467-021-25673-6

Fig. 6. OCN, induced by LRP1 depletion in HFD-fed mice, promotes blood glucose clearance.

Fig. 6

a Blood OCN levels in human metabolic syndrome patients (MS) and normal lean controls (Ctrl). b–d Blood Glu-, Gla- and total OCN levels in HFD-fed WT and eKO mice. Results for control chow (CC)-fed mice are included in Fig. 1d. e–g OCN and insulin tolerance tests in CC and HFD mice (OTTs in e, ITT in f). The inhibition of maximal sensitivity for insulin and OCN in HFD-fed mice compared to CC-fed ones is presented in g. n = 11 (a), 7 (b–d, WT), 6 (b–d, eKO), 5 (e; f, saline; g, OCN), 4 (f, insulin, CC), 6 (f, insulin, HFD; g, insulin). Data are presented as mean ± SEM. Analysis was unpaired two-tailed Student’s t-test (a–d, g) or two-way ANOVA followed by Fisher’s LSD multiple comparison test (e, f).