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. 2021 Sep 6;11:17733. doi: 10.1038/s41598-021-97148-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A high-throughput, high-content PINK-1/PINK1 stabilization screen yielded eight hit compounds. (a) The accumulation of PINK-1/PINK1 in the outer mitochondrial membrane of damaged mitochondria initiates mitophagy. 45,000 compounds were screened in C. elegans resulting in eight PINK-1/PINK1 stabilizers. (b) Fluorescent (raw) and cell profiler-processed (processed) images of C. elegans carrying Ppink-1::PINK-1/PINK1::GFP or N2 wild-type after 24 h of treatment with Na₂SeO₃, PS135, or DMSO control. Representative images are shown. (c) Quantification of GFP fluorescence of C. elegans carrying Ppink-1::PINK-1/PINK1::GFP after 72 h treatment with 7 mM Na₂SeO₃ or DMSO control. Three biological replicates for (b, c) were performed and analyzed.