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. 2021 Sep 6;11:17733. doi: 10.1038/s41598-021-97148-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PS83 and PS106 reduced the rate of paralysis in C. elegans strain expressing human beta-amyloid. (a–e) Rate of paralysis curve of C. elegans Alzheimer’s model (GMC101) expressing full-length human beta-amyloid upon treatment with (a, d) 5 µM PS83, (b, e) 25 µM PS106, or (c) 100 mM metformin control. In (d, e), worms were reared on E. coli expressing cdc-25.1(RNAi)/vector(RNAi) or cdc-25.1(RNAi)/pink-1(RNAi). At least three biological replicates with ~ 180 worms/replicate were analyzed. p-values were determined from Student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001. Black stars indicate significance compared to DMSO control. Red stars in (d, e) indicate statistical significance between PS compound on vector versus pink-1(RNAi)-reared animals.