Table 1.

Summary of PS compounds’ effects on various mitochondrial parameters and other cellular pathways.

	PS30	PS34	PS83	PS103	PS106	PS127	PS135	PS143
Mt fragmentaton	High	High	Low	Mid	Mid	High	Mid	High
Autophagosome formation	High	Less	Mid	Mid	Mid	Less	Mid	Less
Autophagolysosome formation	NS	High	NS	NS	NS	High	NS	High
ATP depletion	High	High	NS	NS	NS	High	High	High
O2 consumption rate reduction	NS	High	NS	NS	NS	High	NS	NS
Mt mass reduction	NS	High	NS	NS	NS	High	NS	NS
Mt ΔΨ reduction	High	NS	NS	High	Mid	NS	High	NS
ROS formation	NS	NS	NS	NS	NS	NS	NS	NS
GST-4 (SKN-1/Nrf2) induction	NS	Mid	Mid	NS	NS	Mid	NS	Mid
DAF-16/FOXO nuclear loc	NS	High	High	NS	NS	High	NS	High
IRG-5 (immune response)	High	NS	NS	NS	NS	NS	High	High

NS not significant.