Fig. 8. Mapping of known mutations of Pdr5.

Functional mutants of Pdr5 found in literature (see: Supplementary Table 5) are mapped onto the cartoon representation of inward-facing Pdr5 structure (R6G-Pdr5). Front and back views are shown. Mutations are highlighted as coloured spheres centred on the C_α of the residue, while the bound ligand, rhodamine 6G, is shown in sticks representation. Mutations that inactivate Pdr5 are labelled with green spheres, those that confer or alter drug resistance with orange and cyan spheres, respectively. Those with other, different phenotypes (see: Supplementary Table 5) are highlighted with magenta. Colour-coding of domains of Pdr5 is identical to Fig. 1 and used throughout.