Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 6;12:5285. doi: 10.1038/s41467-021-25521-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a Venn diagram shows the overlap between promoter methylation concurrence altered genes and average methylation altered genes in TCGA uterus tumor (UCEC). P1, methylation concurrence elevated but average methylation stable genes; P2, hypermethylated but concurrence-stable genes; P3, concurrence-elevated and hypermethylated genes. b Average profiles of methylation concurrence (upper panel) and average methylation (lower panel) in TSS regions of P1, P2, and P3 genes. UCEC normal is in blue, and UCEC tumor is in red. c Gene expression change of P1, P2, P3, and 1000 randomly selected genes. The fold changes between median values (log2 scale) are indicated below. The two-tailed Wilcoxon signed-rank test was used for the significance test. The line in the box center refers to the median, the limits of box refer to the 25th and 75th percentiles and whiskers are plotted at the highest and lowest points within the 1.5 times interquartile range. The lists of repressed genes in three groups are in Supplementary Data 2. d COSMIC tumor suppressor genes which are overlapped with P1, P2, and P3 genes. Gene expression fold changes (log2 scale) are indicated. Darker green signifies higher repression in the UCEC tumor sample. e The percentages of tumor suppressors in P1, P2, and P3 genes.