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. 2021 Sep 6;12:5271. doi: 10.1038/s41467-021-25605-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — 2Q1 variant CAR T cells were co-incubated with RPMI-6666 cells pulsed with either IDH2^R140Q or IDH2^WT peptides at an effector-to-target (E:T) ratio of 1:1. a T-cell activation, as assessed by IFN-γ release, was measured by ELISA. Bars represent the mean of three technical replicates ± SD, while open circles represent the individual data points. b Cytotoxicity was measured by Steady-Glo. Bars represent the mean of three technical replicates ± SD, while open circles represent the individual data points. Source data are provided as a Source data file.